CAS No: 50-63-5
Identified uses : Laboratory chemicals, Manufacture of substances, Science and Development
Chloroquine is a medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects.Chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is also being studied to treat COVID-19 as of 2020. It is taken by mouth.
As of April 3rd, 2020 there is limited evidence to support the use of chloroquine in COVID-19. In late January 2020 during the 2019–20 coronavirus pandemic, Chinese medical researchers stated that exploratory research into chloroquine seemed to have "fairly good inhibitory effects" on the SARS-CoV-2 virus
Chloroquine has been approved by Chinese, South Korean and Italian health authorities for the experimental treatment of COVID-19.
On March 28, 2020 the FDA authorized the use of hydroxychloroquine and chloroquine under an Emergency Use Authorization. The treatment has not been approved by the FDA. The experimental treatment is authorized only for emergency use for people who are hospitalized but not able to receive treatment in a clinical trial.
Chloroquine had been also proposed as a treatment for SARS, with in vitro tests inhibiting the SARS-CoV virus. In October 2004, a group of researchers at the Rega Institute for Medical Research published a report on chloroquine, stating that chloroquine acts as an effective inhibitor of the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro.
Chloroquine was being considered in 2003, in pre-clinical models as a potential agent against chikungunya fever.